Pubmed

• From breakdown to repair: A human organoid model of menstruation 8 mai 2026
  Menstruation entails repeated cycles of cyclical shedding and scarless regeneration of the endometrium, yet the precise cellular states underlying this process have remained poorly defined. In this issue, Nikolakopoulou et al. establish an in vitro menstrual cycle (IVMC) protocol using human endometrial organoids, revealing WNT7A as a central regulator of epithelial regeneration.
  Elisa T Zhang
• How ever-expanding organoids from epithelial stem cells were developed: A hypothesis-free approach 8 mai 2026
  No abstract
  Hans Clevers
• Persistence of alveolar fibroblast-derived ADAMTS4+ cells in a preclinical model of delayed pulmonary fibrosis resolution 8 mai 2026
  Idiopathic pulmonary fibrosis is the most common and aggressive form of interstitial lung disease. Despite extensive research on the pathomechanisms of fibrogenesis, little is known about the mechanisms of fibrosis resolution. Here, lineage tracing of alveolar fibroblasts was carried out during fibrosis development and delayed resolution in aged mice. Histological analyses, single-cell transcriptomics, and ex […]
  Mahsa Zabihi
• Author Correction: Chemically-defined and scalable culture system for intestinal stem cells derived from human intestinal organoids 8 mai 2026
  No abstract
  Ohman Kwon
• SCOTCH: isoform-level characterization of gene expression through long-read single-cell RNA sequencing 7 mai 2026
  Recent advances in long-read single-cell transcriptome sequencing (lr-scRNA-Seq) enable full-length isoform profiling at single-cell resolution. We present SCOTCH (Single-Cell Omics for Transcriptome CHaracterization), an end-to-end, platform-independent pipeline for isoform characterization from lr-scRNA-Seq data, supporting Nanopore and PacBio sequencing as well as 10X Genomics and Parse Biosciences protocols. SCOTCH models isoforms as combinations of non-overlapping sub-exons […]
  Zhuoran Xu
• MELK inhibition disrupts actin cytoskeleton and broadly restricts human coronavirus infections 6 mai 2026
  Protein kinases regulate numerous critical biological processes in eukaryotic cells and are important targets for drug development. However, the common functional protein kinases and corresponding inhibitors with broad-spectrum therapeutic potential for human coronavirus infections remain largely unknown. By integrating global phosphoproteomics and high-content screening, we identify maternal embryonic leucine zipper kinase (MELK) as a common […]
  Kuai Yu
• Human adherent cortical organoids in a multi-well format 5 mai 2026
  In the growing diversity of human induced pluripotent stem cell (iPSC)-derived models of brain development, we present here a novel method that exhibits 3D cortical layer formation in a reproducible topography of minimal dimensions. The resulting adherent cortical organoids (ACOs) develop by self-organization after seeding frontal cortex-patterned iPSC-derived neural progenitor cells in 384-well plates during […]
  Mark van der Kroeg
• Transplantation of human stem cell-derived cone photoreceptors partially restores vision in aged rd1 mice with advanced retinal degeneration 4 mai 2026
  Targeted photoreceptor replacement therapy is a promising, potentially disease-agnostic approach for reversing sight-loss associated with advanced retinal degenerations, including age-related macular degeneration. We have previously shown that transplantation of human stem cell-derived cone photoreceptors (hCones) into young adult (3-month-old) mouse models of advanced retinal degeneration can restore retinal function. However, substantial remodeling of the remaining […]
  Christopher A Procyk
• Targeting FGFR signaling overcomes therapeutic resistance and immune evasion in oncogenic PIK3CA-driven serous-like endometrial cancer 4 mai 2026
  Serous endometrial cancer (SEC) is an aggressive subtype of endometrial cancer (EC) with poor prognosis and limited treatment options. Here, we develop a clinically relevant, immunocompetent serous-like mouse model incorporating oncogenic PIK3CA mutation, Trp53 loss, and MYC overexpression. Using this model together with human EC cell lines, patient-derived organoids (PDOs), xenografts, and patient datasets, we […]
  Xin Cheng
• Vertebrate endoderm development 1 mai 2026
  The endoderm forms the innermost layer of the embryonic gut tube. It gives rise to the epithelial and glandular components of many internal organs, including those of the digestive and respiratory systems. Endodermal organs have essential physiological processes such as nutrient absorption, respiration, detoxification and endocrine regulation. Over the past two decades, work in vertebrate […]
  Bailey A T Weatherbee