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3D-HUB-O news
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Human brain cells implanted in rats prompt excitement — and concern
General organoid news, Working groupsAn organoid-based organ-repurposing approach to treat short bowel syndrome (Nature, 2021)
General organoid newsEstablishment of human fetal hepatocyte organoids and CRISPR–Cas9-based gene knockin and knockout in organoid cultures from human liver (Nature Protocols, 2021)
General organoid newsRSS feeds on organoids
Pubmed
- Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with <em>RHO</em> copy number variation 25 avril 2024Retinitis pigmentosa (RP), a heterogenous group of inherited retinal disorder, causes slow progressive vision loss with no effective treatments available. Mutations in the rhodopsin gene (RHO) account for ~25% cases of autosomal dominant RP (adRP). In this study, we describe the disease characteristics of the first-ever reported mono-allelic copy number variation (CNV) in RHO as […]Sangeetha Kandoi
- Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo 24 avril 2024Three-dimensional organoid culture technologies have revolutionized cancer research by allowing for more realistic and scalable reproductions of both tumour and microenvironmental structures^(1-3). This has enabled better modelling of low-complexity cancer cell behaviours that occur over relatively short periods of time⁴. However, available organoid systems do not capture the intricate evolutionary process of cancer development in […]L Francisco Lorenzo-Martín
- MYADM binds human parechovirus 1 and is essential for viral entry 24 avril 2024Human parechoviruses (PeV-A) are increasingly being recognized as a cause of infection in neonates and young infants, leading to a spectrum of clinical manifestations ranging from mild gastrointestinal and respiratory illnesses to severe sepsis and meningitis. However, the host factors required for parechovirus entry and infection remain poorly characterized. Here, using genome-wide CRISPR/Cas9 loss-of-function screens, […]Wenjie Qiao
- Antisense oligonucleotide therapeutic approach for Timothy syndrome 24 avril 2024Timothy syndrome (TS) is a severe, multisystem disorder characterized by autism, epilepsy, long-QT syndrome and other neuropsychiatric conditions¹. TS type 1 (TS1) is caused by a gain-of-function variant in the alternatively spliced and developmentally enriched CACNA1C exon 8A, as opposed to its counterpart exon 8. We previously uncovered several phenotypes in neurons derived from patients […]Xiaoyu Chen
- Mini-colon and brain 'organoids' shed light on cancer and other diseases 24 avril 2024No abstractSara Reardon
- NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development 23 avril 2024While dysfunction and death of light-detecting photoreceptor cells underlie most inherited retinal dystrophies, knowledge of the species-specific details of human rod and cone photoreceptor cell development remains limited. Here, we generate retinal organoids carrying retinal disease-causing variants in NR2E3, as well as isogenic and unrelated controls. Organoids were sampled using single-cell RNA sequencing across the […]Nathaniel K Mullin
- A patient-specific lung cancer assembloid model with heterogeneous tumor microenvironments 20 avril 2024Cancer models play critical roles in basic cancer research and precision medicine. However, current in vitro cancer models are limited by their inability to mimic the three-dimensional architecture and heterogeneous tumor microenvironments (TME) of in vivo tumors. Here, we develop an innovative patient-specific lung cancer assembloid (LCA) model by using droplet microfluidic technology based on […]Yanmei Zhang
- Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells 18 avril 2024Colorectal cancer (CRC) tumors are composed of heterogeneous and plastic cell populations, including a pool of cancer stem cells that express LGR5. Whether these distinct cell populations display different mechanical properties, and how these properties might contribute to metastasis is poorly understood. Using CRC patient derived organoids (PDOs), we find that compared to LGR5- cells, […]Sefora Conti
- The estrogen signaling pathway reprograms prostate cancer cell metabolism and supports proliferation and disease progression 16 avril 2024Just as the androgen receptor (AR), the estrogen receptor α (ERα) is expressed in the prostate and is thought to influence prostate cancer (PCa) biology. Yet, the incomplete understanding of ERα functions in PCa hinders our ability to fully comprehend its clinical relevance and restricts the repurposing of estrogen-targeted therapies for the treatment of this […]Camille Lafront
- Harnessing gastrointestinal organoids for cancer therapy 15 avril 2024Gastrointestinal organoids have emerged as a model system that authentically recapitulates the in vivo situation. Despite biomedical and technical challenges, self-assembled 3D structures derived from pluripotent stem cells or healthy and diseased tissues have proved to be invaluable tools for cancer drug discovery, disease modeling, and studying infection with carcinogenic pathogens.Gunter Maubach
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