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The technology of the organoid culture that we used on the 3D-Hub-O platform, consists in:
- Isolating a population of cells containing stem cells from the tissue of interest
- Defining the best growing media conditions to form organoids that resemble histologically and functionally specific organs or tumors. We have expertise in growing organoids from mouse and human gastrointestinal tissues from normal and tumoral biopsies (stomach, intestine, colon, rectum, anus), normal mammary gland and recently human lung tumors.
List of publications associated with the platform
Organoids: relevant model to reproduce the histological characteristics of the tissue
Traversari E., Bonnet J., Saubin, M.,Triaire S., Poizat F., Ratone J-P., Dahel, Y., Caillol, F., Pesanti C., Comiti, O., Giovannini, M., de Chaisemartin C., Turrini, O., Ginestier C., Charafe-Jauffret, E., Guasch G., Chevrier V
Rev.Fr. Histotechnolo., 2023, in press
Loss of XIST impairs human mammary stem cell differentiation and modulates tumorigenesis through enhancer landscape remodelling
L. Richart, M.-L. Picod, M. Wassef, M. Macario, S. Aflaki, M.A. Salvador, J. Wicinski, V. Chevrier, S. LeCam, H.A. Kamhawi, R. Castellano, G. Guasch, E. Charafe-Jauffret, E. Heard, R. Margueron and C. Ginestier.
Cell. 2022 9;185(12):2164-2183.e25.
A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration after injury
Mitoyan L, Chevrier V, Hernandez-Vargas H, Ollivier A, Homayed Z, Pannequin J, Poizat F, De Biasi-Cador C, Charafe-Jauffret E, Ginestier C, and Guasch G.
Nature Communications 2021 12(1):2761.
Supervisory authorities and funding partners
