3D-Hub-O was created on an independent initiative, publications reflect only the views of the project owner.
3D-Hub Organoids
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    • A framework for neural organoids, assembloids and transplantation studies
    • A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids
    • A microfluidic platform integrating functional vascularized organoids-on-chip
    • A nomenclature consensus for nervous system organoids and assembloids
    • A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly
    • Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia
    • ABOUT 3D-Hub-O
    • Accessible homeostatic gastric organoids reveal secondary cell type-specific host-pathogen interactions in Helicobacter pylori infections
    • Actuation enhances patterning in human neural tube organoids
    • Advances in understanding interferon-mediated immune responses to enteric viruses in intestinal organoids
    • An integrated transcriptomic cell atlas of human neural organoids
    • Androgens increase excitatory neurogenic potential in human brain organoids
    • Antibody-dependent cellular cytotoxicity-inducing antibodies enhance the natural killer cell anti-cancer response against patient-derived pancreatic cancer organoids
    • Astrocyte-secreted cues promote neural maturation and augment activity in human forebrain organoids
    • Beneficial Impact of Interspecies Chimeric Renal Organoids Against a Xenogeneic Immune Response
    • Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids
    • Bladder cancer organoids as a functional system to model different disease stages and therapy response
    • Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids
    • Case report: Artificial thymic organoids facilitate clinical decisions for a patient with a TP63 variant and severe persistent T cell lymphopenia
    • Cellular crosstalk mediated by TGF-beta drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoids
    • CENTRES OF EXPERTISE
    • CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids
    • Chemically-defined and scalable culture system for intestinal stem cells derived from human intestinal organoids
    • Chicken intestinal organoids: a novel method to measure the mode of action of feed additives
    • Clinical trials registers
    • Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids
    • Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons
    • Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids
    • Contact
    • Controlling nephron precursor differentiation to generate proximal-biased kidney organoids with emerging maturity
    • Correction: From spheroids to organoids: next-generation models for CAR-T cell therapy research in solid tumors
    • Dendritic cell phenotype and function in a 3D co-culture model of patient-derived metastatic colorectal cancer organoids
    • Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
    • Differentiation of Pluripotent Stem Cells Into Thymic Epithelial Cells and Generation of Thymic Organoids: Applications for Therapeutic Strategies Against APECED
    • DISEASE MECHANISMS
    • DISSEMINATION
    • Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids
    • Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment
    • DRUG DISCOVERY
    • Dynamic allele usage of X-linked genes ameliorates neurodevelopmental disease phenotypes in brain organoids
    • Effects of Stem Cell Secretome on Opioid Receptors and Neuroplasticity in Cerebral Organoids
    • Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems
    • ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
    • Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids
    • Expertise
    • Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
    • Extracellular vesicles secreted by 3D tumor organoids are enriched for immune regulatory signaling biomolecules compared to conventional 2D glioblastoma cell systems
    • From spheroids to organoids: next-generation models for CAR-T cell therapy research in solid tumors
    • Functional neuronal circuitry and oscillatory dynamics in human brain organoids
    • Generation of 3D lacrimal gland organoids from human pluripotent stem cells
    • Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo
    • Generation of human adult hepatocyte organoids with metabolic functions
    • Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors
    • Generic comparison of lumen nucleation and fusion in epithelial organoids with and without hydrostatic pressure
    • HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids
    • High-resolution positron emission microscopy of patient-derived tumor organoids
    • Human apical-out nasal organoids reveal an essential role of matrix metalloproteinases in airway epithelial differentiation
    • Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity
    • Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases
    • Human fetal brain self-organizes into long-term expanding organoids
    • Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid
    • Human organoids with an autologous tissue-resident immune compartment
    • Human organoids: New strategies and methods for analyzing human development and disease
    • Human pluripotent stem cell-derived skin organoids enabled pathophysiological model of Mycobacterium tuberculosis infection
    • Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction
    • Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
    • Huntington’s disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids
    • Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures
    • Identification of predictive markers for the generation of well-differentiated human induced pluripotent stem cell-derived kidney organoids
    • Immune organoids: emerging platforms for modeling and analyzing human adaptive immunity
    • Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
    • Inferring and perturbing cell fate regulomes in human brain organoids
    • Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids
    • Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity
    • Integrative analysis of multiple genomic data from intrahepatic cholangiocarcinoma organoids enables tumor subtyping
    • Intersection of nanomaterials and organoids technology in biomedicine
    • Islet organoids: a new hope for islet transplantation in diabetes
    • Large-scale CRISPR screening in primary human 3D gastric organoids enables comprehensive dissection of gene-drug interactions
    • Legal Notice
    • Liver organoids: a promising three-dimensional model for insights and innovations in tumor progression and precision medicine of liver cancer
    • Lung cancer organoids analyzed on microwell arrays predict drug responses of patients within a week
    • Macrophage-augmented intestinal organoids model virus-host interactions in enteric viral diseases and facilitate therapeutic development
    • Magnetically reshapable 3D multi-electrode arrays of liquid metals for electrophysiological analysis of brain organoids
    • Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth
    • Maturation and circuit integration of transplanted human cortical organoids
    • Mechanical plasticity of collagen directs branch elongation in human mammary gland organoids
    • Mechanically induced development and maturation of 3D in-vitro organoid platform: an organotypic heterogeneous microphysiological model of patient-derived organoids with ER/PR/HER2(+) breast cancer
    • Mice hepatic organoids for modeling nonalcoholic fatty liver disease and drug response
    • Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
    • Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes
    • Modeling neurodegeneration with mutant-tau organoids
    • Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming
    • Monkeypox virus spreads from cell-to-cell and leads to neuronal death in human neural organoids
    • Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition
    • Multi-zonal liver organoids from human pluripotent stem cells
    • Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex
    • Multiplexed bulk and single-cell RNA-seq hybrid enables cost-efficient disease modeling with chimeric organoids
    • Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure
    • Neutrophils aggravate inflammatory lesions in intestinal organoids from necrotizing enterocolitis
    • News
    • One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids
    • Optimized Culture Conditions for Improved Growth and Functional Differentiation of Mouse and Human Colon Organoids
    • Organoid service platforms
    • Organoids and microphysiological systems: Promising models for accelerating AAV gene therapy studies
    • Organoids transplantation attenuates intestinal ischemia/reperfusion injury in mice through L-Malic acid-mediated M2 macrophage polarization
    • Organoids: new frontiers in tumor immune microenvironment research
    • Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease
    • Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis
    • Patient-derived xenografts and organoids model therapy response in prostate cancer
    • Physiological hypoxia improves growth and functional differentiation of human intestinal epithelial organoids
    • Platform access
    • Privacy
    • Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex
    • RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis
    • Rapid and scalable personalized ASO screening in patient-derived organoids
    • Recapitulating dengue virus infection with human pluripotent stem cell-derived liver organoids for antiviral screening
    • Recapitulating hypoxic metabolism in cartilaginous organoids via adaptive cell-matrix interactions enhances histone lactylation and cartilage regeneration
    • Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening
    • RESEARCH
    • RESOURCES
    • Retinoblastoma from human stem cell-derived retinal organoids
    • SARS-CoV-2 infection and replication in human gastric organoids
    • Scalable production of uniform and mature organoids in a 3D geometrically-engineered permeable membrane
    • Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoids
    • Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
    • Services
    • Simultaneous profiling of RNA isoforms and chromatin accessibility of single cells of human retinal organoids
    • Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
    • Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids
    • Spatially-restricted inflammation-induced senescent-like glia in multiple sclerosis and patient-derived organoids
    • Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids
    • Spin glasses, error correcting codes, and synchronization of human stem cell organoids
    • Survival and functional integration of human embryonic stem cell-derived retinal organoids after shipping and transplantation into retinal degeneration rats
    • Targeted antisense oligonucleotide treatment rescues developmental alterations in spinal muscular atrophy organoids
    • Temporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identity
    • The drug-induced phenotypic landscape of colorectal cancer organoids
    • The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi
    • Three-dimensional liquid metal-based neuro-interfaces for human hippocampal organoids
    • Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids
    • Training
    • Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
    • Tumour necrosis factor-alpha induces macromolecule translocation in HIV-derived duodenal organoids
    • Understanding disruption of the gut barrier during inflammation: Should we abandon traditional epithelial cell lines and switch to intestinal organoids?
    • Visualizing PIEZO1 localization and activity in hiPSC-derived single cells and organoids with HaloTag technology
    • Volumetric compression regulates the phase separation of AXIN and acts as an operational amplifier to bidirectionally modulate Wnt signaling in organoids
    • Welcome
    • WORKING GROUPS
    • Xenotransplanted human organoids identify transepithelial zinc transport as a key mediator of intestinal adaptation
    • Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids
    • γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids

    Catégories

    • 3D-HUB-O news
    • Centre for expertise
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    • General organoid news
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    Archive

    • août 2024
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    • octobre 2023
    • juillet 2023
    • octobre 2022
    • mars 2021
    • février 2021

    About this website

    The 3D-Hub-O website was created on an independent initiative, publications reflect only the views of the project owner.

    Contact

    Email : organoide.3d-hub-o@inserm.fr
    Centre de Recherche en Cancérologie de Marseille
    27 bd Lei Roure
    13273 Marseille cedex 09

    3D-HUB-O PLATFORM DIRECTION

    Scientific manager: Géraldine GUASCH
    Technical manager: Véronique CHEVRIER

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